Bitcoin DeFi Project BOB and LayerZero Enable Native BTC Transfers Across 11 Blockchains

Crypto Moda Daily Market Report — September 30, 2025

In a major breakthrough for interoperability, the Bitcoin DeFi project BOB has partnered with LayerZero to launch native Bitcoin transfers across 11 major blockchains, according to CoinDesk. This development marks a milestone for Bitcoin’s role in decentralized finance (DeFi), long limited by its lack of cross-chain functionality.

🚀 Breaking Down the Integration

Until now, most Bitcoin activity in DeFi relied on wrapped tokens like WBTC or synthetic representations on other chains. The BOB + LayerZero collaboration changes this by enabling:

  • Direct, native Bitcoin transfers without relying on intermediaries.

  • Cross-chain interoperability spanning 11 blockchains, including Ethereum, Solana, Polygon, and Avalanche.

  • Greater security and transparency, eliminating some of the risks associated with custodial wrapping.

🌐 Why This Matters

Bitcoin has always been the largest and most secure blockchain, but it lagged in DeFi adoption due to its limited programmability. By unlocking native BTC transfers across multiple chains, BOB and LayerZero are creating opportunities for:

  • DeFi protocols to integrate Bitcoin liquidity directly.

  • Users to deploy BTC in lending, staking, and trading without relying on wrapped assets.

  • Developers to expand Bitcoin’s utility beyond a store of value.

📈 The Bigger Picture

This advancement could reshape the DeFi landscape by making Bitcoin a true cross-chain asset, bridging the gap between its massive liquidity and the vibrant ecosystems of programmable blockchains.

For investors, this represents not only a boost in Bitcoin’s utility but also a step toward greater DeFi maturity, where assets move seamlessly across ecosystems.

As more protocols adopt this integration, Bitcoin may finally achieve a long-awaited role: the backbone of decentralized finance across the entire blockchain economy.

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